‘Brain fingerprinting’ of adolescents might be able to predict mental health problems down the line | 白菜大全论坛 | 白菜大全论坛, 昆士兰, 澳大利亚

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‘Brain fingerprinting’ of adolescents might be able to predict mental health problems down the line

2022年8月15日

Despite the best efforts of clinicians 而且 researchers for decades, we still do not fully know why some people develop mental disorders 而且 others do not. However, changes in the brain are very likely our best clues to future mental health outcomes.

The adolescent brain is particularly important in this pursuit as changes during this period are rapid 而且 动态塑造白菜大全论坛个人的独特性. 此外,大多数精神障碍 出现 during adolescence, with more than half occurring by 14 years of age, three quarters by age 25.

By monitoring 而且 tracking brain changes as they happen, we can tackle emerging mental health problems in adolescence 而且 target early treatment. The challenge is accurately predicting the likelihood of a person developing a mental disorder, 在它发生之前.

We are researchers with the world-first Longitudinal Adolescent Brain 研究 (LABS). We have been tracking adolescent brain development, using 核磁共振成像 scans, for several years. 白菜大全论坛最近的 is the first to show the uniqueness of an adolescent’s brain (or their “脑指纹)可以预测心理健康结果.

Brain fingerprinting could be the future of mental disorder prevention, allowing us to identify signs of concern in teenagers through brain imaging, 并在疾病发展之前尽早进行干预.

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作者

扎克博士山
Senior 研究 Fellow | Head of Neuroimaging Platform, 汤普森研究所
教授丹尼尔Hermens
Professor of Youth Mental Health 而且 神经生物学, 汤普森研究所
吉姆Lagopoulos教授
导演,汤普森研究所

 

白菜大全论坛独特的大脑在发挥作用

就像指纹是独一无二的一样, each human brain has a unique profile of signals between brain regions that 变得更加个性化和专业化 随着人们年龄的增长.

到目前为止, 白菜大全论坛的研究涉及125名参与者, 从12岁开始, 其中有500多张脑部扫描图. Our research captures brain 而且 mental health development in adolescents over five years. 它使用了四个月的大脑成像(核磁共振成像 而且 脑电图描记器),以及心理和认知评估.

白菜大全论坛研究了每个人的 功能连接体 -他们大脑的神经通路系统在起作用. We discovered that how unique these characteristics are is significantly associated with new 心理压力 reported at the time of subsequent scans four months later. In other words, the level of uniqueness seems to be predictive of a mental health outcome.

核磁共振扫描是在 静息状态而不是基于任务的功能性核磁共振成像. 它仍然能告诉白菜大全论坛很多白菜大全论坛大脑活动的信息, such as how the brain keeps connections running or gets ready to do something. You could compare this to a mechanic, listening to a engine idling before it’s taken for a drive.

In the 12-year-olds we studied, we found unique functional whole-brain connectomes do exist. 而是一个更具体的网络,涉及控制 目标导向行为 -在青春期早期就不那么独特了. In other words, this network is still quite similar across different people.

We found the extent of its uniqueness can predict anxiety 而且 depression symptoms that 出现 later. So those with less unique brains had higher levels of distress down the line.

丰富的见解

We suspect the level of maturation in this brain network – the part that involves executive control or 目标导向行为s – may provide a biological explanation for why some teens are at increased vulnerability of mental distress. It may be that delays in the “fine tuning” of such executive function networks lead to increased mental health issues.

By doing brains scans 而且 other assessments at regular intervals – up to 15 times for each participant – LABS not only provides fine-grained information about adolescent brain development, but it can also better pinpoint the 出现nce 而且 onset of mental ill health.

Our approach allows us to better establish the occurrence 而且 sequence of changes in the brain (而且 in behaviours, 生活方式因素, 思维)和心理健康风险和问题.

In addition to unique brain signatures to predict 心理压力, 白菜大全论坛期望会有其他的方式(使用 机器学习) we can interpret information about a person’s brain. This will get us closer to accurately predicting their mental health 而且 wellbeing outcomes. Data rich, studies over a long time period are the key to finding this “holy grail” of neuroscience.

Identifying mental health risk in teenagers means we may be able to intervene before adulthood, when many mental health disorders become embedded 而且 more difficult to resolve.

值得的

This vision for the future of mental health care offers hope in the wake of recent statistics from the 2020–21 全国心理健康和幸福研究. They revealed two in five 澳大利亚ns aged 16 to 24 had a mental disorder within the previous year, 是所有年龄段中死亡率最高的. This is a jump of 50% since the last national survey in 2007.

花了110亿美元 on mental health-related services in 澳大利亚 every year, better prevention via early detection should be an urgent priority.

丹尼尔Hermens,青年心理健康教授 & 神经生物学, 白菜大全论坛; 吉姆Lagopoulos汤普生研究所所长, 白菜大全论坛, 扎克山,高级研究员, 白菜大全论坛

本文转载自 谈话 根据知识共享许可协议. 读了 原文.

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